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Bowel mucosa, and integrity of the intestinal epithelial barrier, is protected by IL-17, 57 meaning its removal will eventually disrupt this barrier leading to further penetration of bacteria and worsening of inflammation

Generally, it happens in conditions with low blood flow to the liver resulting in insufficient perfusion such as liver resections and transplantation (83), cardiogenic and hemorrhagic shock, surgical cutting, cardiovascular or laparoscopic surgery and abdominal compartment syndromes (84, 85)

GLP- 1-based therapy exerts its pharmacological effects by activating the GLP- 1 receptor, a class of G protein-coupled receptor consisting of 463 amino acids

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